The Generative AI-SynBio Blue-Green-Structures of the FIU-Carbon-Positive Design Studio led by Prof. Thomas Spiegelhalter is a four years global research project in different locations and climate zones. The project involves collecting and analyzing geospatial climatic data using data-driven Generative AI-ML, Generative Adversarial Networks, and Cellular Automata design methods to create carbon-positive and renewable energy-powered cities, buildings, and infrastructure scenarios. In addition, the design studio is exploring innovative solutions for circular metabolism and self-sufficient green-blue adaptive infrastructures that can adapt to climate change’s impacts, such as heat waves, sea-level rise, storm surge, and resource scarcity in the low-lying Miami island areas.